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Effect of cholecystokinin (CCK; 5 pmol) in pancreatic amylase output of the isolated rat pancreas under 5.6 mM glucose (G) background. Each point (○; 3 months old rats (M), ■; 12 months old rats (M), ♦; 18 months old rats (M) and bar (□; 3M, ■; 12M, ▨; 18M) represent the mean±S.E of 6 experiments. Cumulative amlylase output was calculated from the sum of CCK effect minus basal secretion for 60 min. ND; no significant difference.
