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The equivalent circuit of a patched membrane with a fused vesicle. The cell-attached patch-clamp configuration enables the detection of vesicle fusion in the patched membrane region (A). In the equivalent circuit, the fusion of a vesicle is considered in parallel to the patch membrane (B). Note that RA is the access resistance, Cm is the whole-cell membrane capacitance, GM is the membrane conductance, Cv is the vesicle membrane capacitance, and Gp is the fusion-pore conductance.
