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. 2013 Mar 12;32(7):970–981. doi: 10.1038/emboj.2013.50

Figure 1.

Figure 1

Radial NSCs in the adult hippocampus express p57. (A) p57 is expressed in adult hippocampal radial NSCs. Immunohistochemistry on brain sections of 3-month-old mice showing GFAP (blue), Nestin (red), and p57 (green) triple-labelled cells projecting radially from the SGZ of the DG (arrowhead). Nuclei were counterstained with Hoechst. Scale bar, 5 μm. (B–F) Expression of p57 in differentiated cell populations in the SGZ/GCL. Strong p57 staining was detected in DCX+ cells (D) and some S100β+ cells (F), but not in the majority of Ascl1+ IPCs (B), BrdU+ proliferating cells (2 h pulse, C) and NeuN+ mature neurons (E). Arrowheads indicate differentiated cell populations. Nuclei were counterstained with Hoechst (blue). Scale bar, 10 μm.