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. 2013 Mar 12;32(7):970–981. doi: 10.1038/emboj.2013.50

Figure 3.

Figure 3

Reduction of p57 contributes to radial NSC activation induced by running. (A) Two-month-old female mice initially housed in small cages without a running wheel were exposed to spacious housing with running wheels (run) or small housing (control) for 12 days and then sacrificed. (B) The staining intensity of p57 was measured in the nucleus of radial NSCs identified by their radial morphology and expression of GFAP and Nestin. The intensity of each nucleus was plotted for comparison. Red horizontal bar represents average staining intensity. n=3 for both control and run. (C) Two-month-old female mice initially housed in small cages without a running wheel were administered with tamoxifen and then exposed to spacious housing with running wheels (run) or small housing (control) for 12 days and then sacrificed. (D) Quantification of PCNA+ radial NSCs in the SGZ. Three control and p57 cKO mice were exposed to small housing and four control and three p57 cKO mice were exposed to spacious housing with running wheels. Values represent mean±s.e.m. ***P<0.001; *P<0.05; Student’s t-test.