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. 2013 Mar 12;32(7):970–981. doi: 10.1038/emboj.2013.50

Figure 7.

Figure 7

A model for the regulation and significance of hippocampal NSC quiescence. (A) In wild-type mice, p57 restricts the proliferation of hippocampal radial NSCs. Reduction of p57 protein in NSCs contributes to the abrogation of NSC quiescence triggered by various extrinsic neurogenic stimuli. (B) Selective deletion of p57 in NSCs initially enhances NSC proliferation and neurogenesis in young adult mouse, but later leads to the NSC exhaustion and excessive reduction of neurogenesis in aged mice, suggesting that regulation of NSC quiescence by p57 is significant in modulating the pace of lifelong neurogenesis. (C) Acute p57 deletion in aged mice reactivates hippocampal NSC proliferation and neurogenesis.