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. Author manuscript; available in PMC: 2013 Apr 4.
Published in final edited form as: Pharmacol Rev. 2011 Nov 21;64(1):166–187. doi: 10.1124/pr.110.003905

Figure 6. NAD+ as a nodal point for metabolic regulation.

Figure 6

Most evidence to date points out that NAD+ could be rate-limiting for the SIRT1 reaction in diverse conditions. SIRT1 activity would hence be stimulated by interventions which increase NAD+ levels, such as AMPK activation, enhancement of NAD+ biosynthesis through precursor (NA, NR, NMN) supplementation, or through inhibition of alternative NAD+ consuming activities, such as PARPs or CD38. The stimulation of SIRT1 activity by these distinct means improves the capacity of the cells/organism to adapt to external metabolic cues.