Table 1.
Baseline Characteristics by Family History of Colorectal Cancer.
| Family History of Colorectal Cancer | |||
|---|---|---|---|
| No | Yes# | p-value* | |
| No. of patients | 892 | 195 | |
| Age, median (range), years | 60 (24-85) | 63 (21-85) | 0.24† |
| Male (%) | 488 (55) | 119 (61) | 0.11 |
| Race (%) | |||
| White | 789 (89) | 171 (88) | 0.83 |
| Black | 61 (7) | 14 (7) | |
| Other | 39 (4) | 10 (5) | |
| Performance Status± (%) | |||
| 0 | 658 (75) | 139 (73) | 0.52 |
| 1-2 | 214 (25) | 51 (27) | |
| Body mass-index, median (range), kg/m2 |
27.3 (15.6-51.7) | 26.8 (17.5-49.3) | 0.32† |
| Treatment Arm (%) | |||
| FU/LV | 446 (50) | 102 (52) | 0.58 |
| IFL | 446 50) | 93 (48) | |
| Tumor Location (%) | |||
| Right colon | 486 (56) | 115 (61) | 0.26 |
| Left colon | 385 (44) | 75 (39) | |
| Post-op CEA (%) | |||
| ≤ 5 | 765 (92) | 168 (94) | 0.28 |
| >5 | 69 (8) | 10 (6) | |
| Invasion through bowel wall† (%) | |||
| T1-2 | 117 (13) | 25 (13) | 0.99 |
| T3-4 | 753 (87) | 165 (87) | |
| Positive lymph nodes (%) | |||
| 1-3 | 553 (63) | 124 (65) | 0.17 |
| ≥ 4 | 321 (37) | 66 (35) | |
| Tumor differentiation (%) | |||
| Well | 52 (6) | 9 (5) | 0.70 |
| Moderate | 616 (71) | 133 (70) | |
| Poor | 203 (23) | 49 (26) | |
| Clinical Bowel Obstruction (%) | 212 (24) | 31 (16) | 0.02 |
| Clinical Bowel Perforation (%) | 37 (4) | 11 (6) | 0.34 |
| Smoking Status (%) | |||
| Current | 80 (9) | 27 (14) | 0.13 |
| Past | 393 (45) | 85 (44) | |
| Never | 408 (46) | 83 (43) | |
| Median household income in 1999φ, median (range) |
$40,542 ($20,480-$122,956) |
$41,367 ($17,963-$97,918) |
0.26† |
| Physical Activity, median (range), MET h/wk |
4.9 (0-125.2) | 4.5 (0-147.4) | 0.48 |
| Dietary Intake [median (range)] | |||
| Red meat, servings/wk | 3.2 (0-22.6) | 3.2 (0-15.1) | 0.80† |
| Processed meats, servings/wk | 2.4 (0-33.0) | 2.6 (0-16.0) | 0.15† |
| Refined grains, servings/d | 3.2 (0-21.6) | 2.9 (0.5-16.3) | 0.38† |
| Dessert, servings/d | 1.2 (0-10.8) | 1.1 (0-19.3) | 0.84† |
| Total fat, g/d | 73.6 (0-127.6) | 75.0 (26.8-117.2) | 0.50† |
Note: Age, body-mass index, performances status, and postoperative CEA were based on patient status at initiation of chemotherapy (entry into the treatment trial).
Abbreviations: CEA, carcinoembryonic antigen; PS, performance status; FU, 5-fluorouracil; LV, leucovorin; IFL, irinotecan, 5-FU, and leucovorin; MET, metabolic equivalent tasks.
By χ2test unless otherwise noted.
By Wilcoxon rank sum.
A performance status of 0 indicates the patient was fully active; PS 1, restricted in physically strenuous activity but ambulatory and able to carry out light work; PS 2, ambulatory and capable of all self-care but unable to carry out any work activities, up and about more than 50% of waking hours.
A grade of T1 or T2 indicates the level of invasion was through the bowel wall not beyond the muscle layer; T3 or T4, the level of invasion was through the bowel wall beyond the muscle layer.
Median household income was determined based on the median household income in the patient’s zip code area according to the US National Census in 2000.
Percentages may not add to 100 due to rounding.