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. Author manuscript; available in PMC: 2013 Apr 4.
Published in final edited form as: Ann Rheum Dis. 2013 Apr;72(0 2):ii111–ii115. doi: 10.1136/annrheumdis-2012-202576

Figure 2. Jakinibs block multiple aspects of cytokine signaling.

Figure 2

Cytokine binding to its cognate receptor leads to phosphorylation of the intracellular domain of the tyrosine kinase receptor by specific Jaks. STATs are then recruited, bind to the receptor and become phosphorylated by Jaks. This results in STAT dimerization, translocation, and regulation of gene transcription. Cytokines also activate the PKB (Akt) and mTOR. Though not carefully studied, it is highly likely that blocking proximal cytokine signals will disrupt all downstream pathways. ** Also referred to as AKT.