Table 1.
Distribution of worst histologic diagnosis over 2003–2010 among women aged 21–24 at baseline by baseline Pap result (with HPV test triage of ASC-US).
| Baseline Pap and HPV test result | Total
|
Worst histologic diagnosis during follow-up
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | <CIN1, n | CIN1, n | CIN2, n | CIN3, n | AIS, n | Total CIN3 or AIS, n | Squamous carcinoma, n | Adeno-carcinoma, n | Total cancers, n | |
| Total | 133,947 | 128,608 | 3,840 | 1,078 | 406 | 11 | 418 | 1 | 2 | 3 |
| HSIL | 251 | 114 | 33 | 60 | 43 | 0 | 44 | 0 | 0 | 0 |
| ASC-H | 454 | 232 | 91 | 84 | 46 | 1 | 47 | 0 | 0 | 0 |
| AGC | 87 | 57 | 17 | 7 | 4 | 1 | 5 | 0 | 1 | 1 |
| LSIL | 4,810 | 3,325 | 1,149 | 259 | 77 | 0 | 77 | 0 | 0 | 0 |
| ASC-US | 11,280 | 8,647 | 1,953 | 499 | 176 | 4 | 180 | 1 | 0 | 1 |
| HPV-positive/ASC-US | 6,976 | 4,611 | 1,750 | 451 | 159 | 4 | 163 | 1 | 0 | 1 |
| HPV-negative/ASC-US | 3,680 | 3,517 | 125 | 31 | 7 | 0 | 7 | 0 | 0 | 0 |
| HPV-unknown/ASC-US | 624 | 519 | 78 | 17 | 10 | 0 | 10 | 0 | 0 | 0 |
| Pap-negative | 117,065 | 116,233 | 597 | 169 | 60 | 5 | 65 | 0 | 1 | 1 |
Footnote: Total cancers also includes adenosquamous carcinoma, cervical cancer of unknown histology, and cervical cancer histology unrelated to HPV infection. The category “Total CIN3 or AIS” also includes 1 woman with a diagnosis that did not differentiate between CIN3 and AIS. “<CIN1” means either that no biopsy was taken, or a biopsy was taken but only normal or metaplastic histology was diagnosed.