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. 2013 Mar 28;4(3):e32. doi: 10.1038/ctg.2013.3

Table 1. Randomized controlled trials comparing test-and-treat strategy vs. prompt endoscopy.

Author Year of publication Country Number of patientsa Age limit (years) Setting H. pylori diagnostic methods H. pylori infection prevalencea H. pylori eradication treatmenta H. pylori eradication ratea Follow-up time (months) Outcome measures
Heaney et al.17 1999 UK 52 <45 Secondary care UBT 100% PPI+C+N 78% 12 Dyspeptic symptoms Quality of life
Jones et al.18 1999 UK 141 <45 Primary care Office-based serology 41% Unknownb Unknown 12 Dyspeptic symptoms Costs/use of medical resources
Lassen et al.19c 2000 Denmark 250 No age limitd Primary and secondary care UBT 26% PPI+A+N 87% 12 Dyspeptic symptoms Quality of life Patient satisfaction Costs/use of medical resources
McColl et al.20 2002 UK 356 <55 Secondary care UBT 48% PPI+C+A 84% 12 Dyspeptic symptoms Quality of life Patient satisfaction Costs/use of medical resources
Arents et al.21 2003 The Netherlands 141 <55 Primary care Serology 38% PPI+A+C/N 87 12 Dyspeptic symptoms Quality of life Patient satisfaction Costs/use of medical resources
Hu et al.22 2006 China 78 No age limitd Primary care UBT 53% PPI+C+A Unknowne 12 Dyspeptic symptoms Quality of life Patient satisfaction Costs/use of medical resources
Mahadeva et al.23 2008 Malaysia 222 <45 Primary care UBT 35% PPI+C+A Unknownf 12 Dyspeptic symptoms Patient satisfaction Medication consumption Costs/use of medical resources
Duggan et al.24 2009 UK 198 No age limitd Primary care Near-patient serology 23% PPI+C+N Unknown 12 Dyspeptic symptoms Quality of life Patient satisfaction Costs/use of medical resources

Abbreviation: UBT, 13C-urea breath test.

H. pylori eradication treatment: A, amoxicillin; C, clarithromycin; N, nitroimidazole; PPI, proton pump inhibitor.

a

In the test-and-treat group.

b

No specific regimen was determined, but PPI-based triple therapy was recommended.

c

The long-term results of this study have been published.26

d

Age threshold at 70 years.

e

Eradication rate was found to be 88% locally.

f

Eradication rate was found to be 91% locally.