Table 1. Randomized controlled trials comparing test-and-treat strategy vs. prompt endoscopy.
Author | Year of publication | Country | Number of patientsa | Age limit (years) | Setting | H. pylori diagnostic methods | H. pylori infection prevalencea | H. pylori eradication treatmenta | H. pylori eradication ratea | Follow-up time (months) | Outcome measures |
---|---|---|---|---|---|---|---|---|---|---|---|
Heaney et al.17 | 1999 | UK | 52 | <45 | Secondary care | UBT | 100% | PPI+C+N | 78% | 12 | Dyspeptic symptoms Quality of life |
Jones et al.18 | 1999 | UK | 141 | <45 | Primary care | Office-based serology | 41% | Unknownb | Unknown | 12 | Dyspeptic symptoms Costs/use of medical resources |
Lassen et al.19c | 2000 | Denmark | 250 | No age limitd | Primary and secondary care | UBT | 26% | PPI+A+N | 87% | 12 | Dyspeptic symptoms Quality of life Patient satisfaction Costs/use of medical resources |
McColl et al.20 | 2002 | UK | 356 | <55 | Secondary care | UBT | 48% | PPI+C+A | 84% | 12 | Dyspeptic symptoms Quality of life Patient satisfaction Costs/use of medical resources |
Arents et al.21 | 2003 | The Netherlands | 141 | <55 | Primary care | Serology | 38% | PPI+A+C/N | 87 | 12 | Dyspeptic symptoms Quality of life Patient satisfaction Costs/use of medical resources |
Hu et al.22 | 2006 | China | 78 | No age limitd | Primary care | UBT | 53% | PPI+C+A | Unknowne | 12 | Dyspeptic symptoms Quality of life Patient satisfaction Costs/use of medical resources |
Mahadeva et al.23 | 2008 | Malaysia | 222 | <45 | Primary care | UBT | 35% | PPI+C+A | Unknownf | 12 | Dyspeptic symptoms Patient satisfaction Medication consumption Costs/use of medical resources |
Duggan et al.24 | 2009 | UK | 198 | No age limitd | Primary care | Near-patient serology | 23% | PPI+C+N | Unknown | 12 | Dyspeptic symptoms Quality of life Patient satisfaction Costs/use of medical resources |
Abbreviation: UBT, 13C-urea breath test.
H. pylori eradication treatment: A, amoxicillin; C, clarithromycin; N, nitroimidazole; PPI, proton pump inhibitor.
In the test-and-treat group.
No specific regimen was determined, but PPI-based triple therapy was recommended.
The long-term results of this study have been published.26
Age threshold at 70 years.
Eradication rate was found to be 88% locally.
Eradication rate was found to be 91% locally.