Table 2. Randomized controlled trials comparing test-and-treat strategy with empirical antisecretory therapy.

Author	Year of publication	Country	Number of patientsa	Age limit (years)	Setting	H. pylori diagnostic methods	H. pylori infection prevalencea	H. pylori eradication treatmenta	H. pylori eradication ratea	Follow-up time (months)	Outcome measures
Manes et al.27	2003	Italy	110	<45	Secondary care	UBT	61%	PPI+C+N	94%	12	Dyspeptic symptoms Costs/use of medical resources
Jarbol et al.28	2006	Denmark	250	No age limit	Primary care	UBT	24%	PPI+C+A	Unknown	12	Dyspeptic symptoms Quality of life Patient satisfaction Costs/use of medical resources
Delaney et al.29	2008	UK	343	No age limitb	Primary care	UBT	29%	PPI+C+N	78%	12	Dyspeptic symptoms Quality of life Patient satisfaction Costs/use of medical resources
Duggan et al.24	2009	UK	198	No age limit	Primary care	Near-patient serology test	23%	PPI+C+N	Unknown	12	Dyspeptic symptoms Quality of life Patient satisfaction Costs/use of medical resources

Abbreviation: UBT, ¹³C-urea breath test.

H. pylori eradication treatment: A, amoxicillin; C, clarithromycin; N, nitroimidazole; PPI, proton pump inhibitor.

^aIn the test-and-treat group.

^bAge threshold at 65 years.