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. 2013 Mar 13;10(4):1417–1424. doi: 10.1021/mp3007067

Figure 3.

Figure 3

The selectivity ratio of GCV prodrug hydrolysis: comparing hydrolysis by HCMV protease hydrolysis and Caco-2 cell homogenates. Ganciclovir prodrugs were subjected to hydrolysis by Caco-2 cell homogenate (1 mg/mL) at 37 °C. Samples were taken at different time points and analyzed by HPLC. The selectivity ratio was calculated by determining the ratio of GCV prodrug hydrolyzed by the HCMV A143T/A144T protease (from results shown in Figure 2) versus the extent of prodrug hydrolyzed by Caco-2 cell homogenates. Data are expressed as mean ± SE (n = 6).