Skip to main content
. 2013 Mar 13;10(4):1417–1424. doi: 10.1021/mp3007067

Figure 4.

Figure 4

The selectivity ratio of GCV prodrug hydrolysis: comparing hydrolysis by HCMV protease hydrolysis and human liver microsomes. Ganciclovir prodrugs were subjected to hydrolysis by human liver microsomes (400 μg/mL) at 37 °C. Samples were taken at different time points and analyzed by HPLC. The selectivity ratio was calculated by determining the ratio of GCV-prodrug hydrolyzed by the HCMV A143T/A144T protease (from results shown in Figure 2) versus the extent of prodrug hydrolyzed by the human liver microsomes. Data are expressed as mean ± SE (n = 6).