Table 2.

Minimally Adjusted Association Between Indices of LV Function and R-R Variation or CAN at EDIC Year 16/17

Cardiac Function	Normal R-R (n = 649)	Abnormal R-R (n = 315)	p Value	CAN– (n = 595)	CAN+ (n = 371)	p Value
End-diastolic volume, ml	135.6 ± 1.1	136.3 ± 1.5	0.6895	135.7 ± 1.1	135.9 ± 1.4	0.9121
End-systolic volume, ml	52.5 ± 0.6	52.6 ± 0.9	0.9095	52.7 ± 0.6	52.3 ±	0.8 0.6848
Stroke volume, ml	83.1 ± 0.7	83.7 ± 1.0	0.6057	83.0 ± 0.7	83.6 ± 0.9	0.5920
Ejection fraction, %	61.6 ± 0.3	61.9 ± 0.4	0.4477	61.5 ± 0.3	62.0 ± 0.3	0.2324
Cardiac output, l/min	5.7 ± 0.1	6.2 ± 0.1	<0.0001	5.7 ± 0.1	6.1 ± 0.1	<0.0001
LV mass, gm	134.6 ± 1.0	142.4 ± 1.5	<0.0001	134.4 ± 1.1	141.4 ± 1.4	<0.0001
Mass-to-volume ratio, gm/ml	1.00 ± 0.01	1.06 ± 0.01	<0.0001	1.00 ± 0.01	1.05 ± 0.01	<0.0001

Values are least square mean ± SE, adjusted for concurrent age, sex, cohort assignment (primary/secondary), and machine type. CAN+ included R-R variation <20 plus Valsalva ratio ≤1.5 or a decrease of >10 mm Hg in DBP upon standing as defined in Methods.

DBP = diastolic blood pressure; LV = left ventricular; other abbreviations as in Table 1.