Table 3.
Association Between Indices of LV function and R-R Variation or CAN at EDIC Year 16 to 17 After Adjustment for Traditional Cardiac Risk Factors and Glycemia
| Cardiac Function | Normal R-R (n = 649) |
Abnormal R-R (n = 315) |
p Value | CAN– (n = 595) |
CAN+ (n = 371) |
p Value |
|---|---|---|---|---|---|---|
| End-diastolic volume, ml | 135.9 ± 1.4 | 137.7 ± 1.6 | 0.2866 | 136.3 ± 1.4 | 136.8 ± 1.5 | 0.7277 |
| End-systolic volume, ml | 52.9 ± 0.9 | 53.2 ± 1.0 | 0.7922 | 53.3 ± 0.9 | 52.7 ± 1.0 | 0.5856 |
| Stroke volume, ml | 82.9 ± 0.9 | 84.4 ± 1.0 | 0.1662 | 83.0 ± 0.9 | 84.1 ± 1.0 | 0.2858 |
| Ejection fraction, % | 61.5 ± 0.4 | 61.9 ± 0.4 | 0.3656 | 61.4 ± 0.4 | 62.0 ± 0.4 | 0.1652 |
| Cardiac output, l/min | 5.8 ± 0.1 | 6.2 ± 0.1 | <0.0001 | 5.8 ± 0.1 | 6.1 ± 0.1 | 0.0003 |
| LV mass, gm | 140.3 ± 1.3 | 143.6 ± 1.5 | 0.0352 | 140.7 ± 1.3 | 142.6 ± 1.4 | 0.2155 |
| Mass-to-volume ratio, gm/ml | 1.04 ± 0.01 | 1.06 ± 0.01 | 0.2490 | 1.04 ± 0.01 | 1.05 ± 0.01 | 0.3499 |
Values are least square mean ± SE, adjusted for concurrent age, sex, cohort assignment (primary/secondary), machine type, height, weight, current smoking, current alcohol use, mean SBP, mean HDL, mean LDL, and mean HbA1c. CAN+ included RR variation <20 plus Valsalva ratio <1.5 or a decrease of >10 mm Hg in DBP upon standing as defined in Methods.