Table 4.
Maternal Diagnoses and Complications: Pregnancies resulting in an infant with BPD based on study criteria with and without a biomarker risk present
|
BPD With Biomarker Risk
*
|
||
|---|---|---|
|
No
|
Yes
|
|
| n (%) | n (%) | |
| Sample | ||
| (n = 246) | 164 (66.7) | 82 (33.3) |
| Any Maternal Diagnosis or Complication | ||
| (n = 513,480) | 84 (51.2) | 53 (64.6)† |
| Any Hypertension, Preeclampsia, Eclampsia | 28 (17.1) | 40 (48.8)‡ |
| Hypertension | 28 (17.1) | 40 (48.8)‡ |
| Preeclampsia | 1 (0.6) | 4 (4.9)† |
| Eclampsia | 1 (0.6) | -- |
| Other Specific Pregnancy Complications | ||
| Bleeding/ Abruption/ Previa | 28 (17.1) | 13 (15.9) |
| Cervical Incompetence | 12 (7.3) | 1 (1.2)† |
| Premature rupture of membranes | 3 (1.8) | -- |
| Edema/ Excessive Weight Gain | 2 (1.2) | -- |
| Hypermesis Gravidarium | 1 (0.6) | -- |
| Trauma | 1 (0.6) | -- |
| Other Diagnosed Disorders/ Conditions | ||
| Neoplasms | 3 (1.8) | 1 (1.2) |
| (Liver (1), Leiomyoma of Uterus (1), Neurofibromatosis (1)) |
(Leiomyoma of Uterus (1)) | |
| Blood and Blood Forming Organs | 2 (1.2) | 3 (3.7) |
| (Thalassemia (1), Anemia (1)) | (Sickle-Cell Disease (1), Anemia (1), Thrombocytopenia (1)) |
|
| Endocrine, Metabolic | 4 (2.4) | -- |
| (Hypothyroidism (3), Goiter(1)) | ||
| Nervous System | -- | 4 (4.9)‡ |
| (Epilepsy (3), Hearing Loss (1)) | ||
| Circulatory System | 3 (1.8) | 2 (2.4) |
| (Cardiac dysrhythmia (2), Pulmonary Embolism and Infarction(1)) |
(Heart Failure (1), Cerebral Artery Occlusion (1)) |
|
| Respiratory System | 3 (1.8) | 3 (3.7) |
| (Asthma (1), Pulmonary Edema (1), Pulmonary Insufficiency (1)) |
(Asthma (2), Pulmonary Edema (1)) | |
| Digestive System | 1 (0.6) | -- |
| (Appendicitis (1)) | ||
| Genitourinary | 3 (1.8) | 1 (1.2) |
| (Old Laceration of Cervix (3)) | (Unspecified Disorder of Kidneys and Ureter (1)) |
|
| Skin | -- | 1 (1.2) |
| (Lupus Erythematosus) | ||
| Sample | ||
| (n = 246) | 164 (66.7) | 82 (33.3) |
| Any Maternal Infection | 15 (9.2) | 3 (3.7) |
| Any Uterine Infection ** | 14 (8.5) | 2 (2.4) |
| Any Viral Infection | 1 (0.6) | 1 (1.2) |
| (CMV (1)) | (Cytomegalovirus (1), HIV (1) (Same Pregnancy)) |
|
| Other | ||
| Indomethacin Administration | 106 (64.6) | 51 (62.2) |
*
AFP MoM ≥ 95th percentile (MoM ≥ 1.80), hCG MoM ≥ 95th percentile (MoM ≥ 2.38), or uE3 MoM ≤ 5th percentile (MoM ≤ 0.59).
**
Includes amnionitis, chorioamnionitis, and endometritis (specific diagnoses not coded for full sample in source database(s)).
†
p < .05
‡
p < .01