Table 5.
Infant Characteristics and Specific Outcomes: Pregnancies resulting in an infant with BPD based on study criteria with and without a biomarker risk present
|
BPD With Biomarker Risk
*
|
||
|---|---|---|
|
No (n = 164)
|
Yes (n = 82)
|
|
| Mean (SD) | Mean (SD) | |
| Range | Range | |
| Days Gestation | 186.8 (9.7) 166 – 211 |
190.9 (10.7) § 170 – 223 |
| Birth Weight (grams) | 902.1 (186.8) 509 – 1440 |
838.0 (213.3)‡ 422 - 1375 |
| Head Circumference (cm) ** | 24.3 (1.7) 21 - 29 |
24.5 (2.5) 19 - 34 |
| Head Circumference/ Birth Weight Ratio** | 0.028 (0.004) 0.019 – 0.039 |
0.030 (0.007) ‡ 0.020 – 0.054 |
| Total Days on Ventilator | 26.3 (18.5) 3 - 91 |
30 (22.4) 3 - 110 |
| n (%) | n (%) | |
| SGA † | 7 (4.3) | 22 (26.8)§ |
| Apgar at 1-Minute ≤ 3 | 30 (18.3) | 21 (25.6) |
| Apgar at 5-Minutes ≤ 3 | 9 (5.5) | 2 (2.4) |
| Baby Death in NICU | 2 (1.2) | 3 (3.7) |
| Any Infant Infection | 42 (25.6) | 27 (32.9) |
| Group B Strep | 9 (5.5) | 5 (6.1) |
| Early Bacterial Sepsis | 6 (3.7) | 1 (1.2) |
| Late Bacterial Sepsis | 30 (18.3) | 22 (26.8) |
| Late Fungal Sepsis | -- | 1 (1.2) |
| Retinopathy of Prematurity (ROP) | 98 (59.8) | 54 (65.9) |
| Patent Ductus Arteriosus (PDA) | 138 (84.2) | 63 (76.8) |
| Intraventricular Hemorrhage (IVH) | 73 (44.5) | 17 (20.7) § |
SGA, Small-for-gestational-age; IUGR, intrauterine growth retardation.
*
AFP MoM ≥ 95th percentile (MoM ≥ 1.80), hCG MoM ≥ 95th percentile (MoM ≥ 2.38), or uE3 MoM ≤ 5th percentile (MoM ≤ 0.59).
**
Computed for 56 of those in the BPD nobiomarker risk group and 18 of those in the BPD biomarker risk group who had head circumference data present in the CPQCC database.
†
Birth weight for gestational age ≤ 10th percentile based on smoothed US birth norms (1)
‡
p < .05
§
p < .0