Table 1.

Distribution of worst histologic diagnosis over 2003-2010 by baseline Pap result with (A) HPV triage of ASC-US among women aged 25-29, and (B) cotesting among women aged 30-64.

	Total	Worst histologic diagnosis during follow-up
Baseline Pap and HPV test result	n	<CIN1, n	CIN1, n	CIN2, n	CIN3, n	AIS, n	Total CIN3 or AIS, n	Squamous carcinoma, n	Adeno- carcinoma, n	Total cancers, n
(A) Aged 25-29 at baseline
Total	135,382	129,428	4,037	1250	621	23	645	12	6	22
LSILa	3,236	1,911	981	262	81	1	82	0	0	0
ASC-USa	12,209	8,963	2,292	654	283	9	293	5	2	7
HPV-positive/ASC-US	6,340	3,418	2,034	605	270	8	279	2	2	4
HPV-negative/ASC-US	5,485	5,237	201	34	11	1	12	1	0	1
HPV-unknown/ASC-US	384	308	57	15	2	0	2	2	0	2
Pap-negativea	118,684	117,936	554	127	61	2	63	1	1	4
(B) Aged 30-64 at baseline
Total	965,360	942,657	15,357	4235	2480	228	2723	198	114	388
$\stackrel{‒}{L}$SILa	9,374	4,845	3,414	780	315	8	325	6	2	10
ASC-USa	27,050	21,714	3,894	927	448	28	479	16	11	36
HPV-positive/ASC-US	9,901	5,285	3,314	844	404	25	432	11	9	26
HPV-negative/ASC-US	16,326	15,708	511	65	35	2	37	3	1	5
HPV-unknown/ASC-US	823	721	69	18	9	1	10	2	1	5
Pap-negativea	923,152	913,113	7,259	1716	836	106	946	41	52	118
HPV-negative/Pap-negativeb	836,803	831,843	3,990	675	224	22	247	21	16	48

Total cancers includes not only squamous cell carcinoma and adenocarcinoma but also adenosquamous carcinoma, and cervical cancer of unknown histology or histology unrelated to HPV infection. The category “Total CIN3 or AIS” also includes women with diagnoses that did not differentiate between CIN3 and AIS. “<CIN1” is included for completeness, and includes normal or metaplastic biopsy findings, no biopsy taken, and no record of colposcopy found.

^aBaseline Pap result alone (regardless of HPV test result)

^bHPV-positive/Pap-negative results are not presented here but addressed in a separate paper (1)