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. Author manuscript; available in PMC: 2013 Apr 4.
Published in final edited form as: Sci Transl Med. 2011 Apr 20;3(79):79ps13. doi: 10.1126/scitranslmed.3001863

Figure 1. Timeline of HIV vaccine efficacy trials.

Figure 1

Shown is a time course of the four major clinical efficacy studies of HIV vaccine candidates performed over the past twenty years. The onset and completion of each trial is noted, together with the time required to evaluate efficacy and laboratory analysis. The Vaxgen studies analyzed the efficacy of a gp120 recombinant protein product, whereas the STEP trial evaluated efficacy of Ad5 viral vectors designed to stimulate T-cell immunity. The RV144 Thai trial tested a canarypox protein combination that stimulated CD4+ T cell and antibody responses.