Figure 3.

VSV induces a transient lymphopenia that is significantly extended by MS-275 coadministration. Ad-hDCT-primed mice (n = 12, pooled data from three experiments) were boosted with VSV-hDCT in the presence of MS-275, MS-275 analogue or carrier. As controls, mice received MS-275 or were untreated. (a) Numbers of cells per µl of blood are displayed over a 30-day period post-treatment. Horizontal dotted line represents average count for untreated mice. (b) CD4⁺, (c) CD8⁺ T cell, and (d) B cell counts are also indicated. Ad, adenoviral; hDCT, human dopachrome tautomerase; VSV, vesicular stomatitis virus.