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Endovascular DES are idealized as phantom interface separating arterial tissue from luminal blood, delivering a fraction fwall of their drug load to the arterial wall and the remaining fraction 1-fwall is cleared by luminal blood. Transmural distribution of absorbed sirolimus is governed by transmural convection and diffusion (Eq. (2)), binding to ECM sites (Eq. (3)), binding to pharmacological receptors (Eq. (4)), and adventitial clearance (Eq. (7)).
