Fig. 5.

Receptor binding state is more sensitive to elution kinetics than dose. Eqs. (2)–(7) were simulated for hypothetical stents that elute 74 μg (lines) or 37 μg (dashes) by pure first order (K_fo =0.53 d⁻¹, black lines) or Higuchi (Q_sus=13.22 μg·d^−1/2, gray lines) kinetics (A). Tissue content (B) and receptor binding levels (C) were evaluated by integrating, respectively, the simulated distributions of total drug and receptor-bound drug across the thickness of the arterial wall. All simulations employed the same tissue transport parameter values (f_wall=0.06, D_wall=2.0×10⁻⁶ cm²/s with all other values listed in Table 2).