Figure 1. Phenotypic characteristics of patients with TGFB2 mutation.

Significant clinical features of individuals with TGFB2 mutations include mild hypertelorism (widely spaced eyes; 1-II:1, 3-III:1 and 7-III:1), malar hypoplasia (flat cheek bones;1-II:1,3-III:1, 4-II:1 and 7-III:1), retrognathia (receding chin; 1-II:1, 3-III:1, 4-II:1 and 7-III:1), arachnodactyly (long fingers; 1-II:1 and 4-II:1), pectus excavatum (7-III:1), pes planus (flat feet; 1-II:1 and 3-III:1) and hammer toes (1-II:1). Permission to publish photographs was obtained from the affected individuals or their parents.