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. Author manuscript; available in PMC: 2013 Apr 4.
Published in final edited form as: Nat Genet. 2012 Jul 8;44(8):922–927. doi: 10.1038/ng.2349

Figure 4. Haploinsufficiency for Tgfb2 causes aortic root aneurysm in mice.

Figure 4

(A.) Parasternal long axis echocardiographic systolic images of the aortic root of 8 month old wild type (n=10), Tgfb2+/− (n=6), and Fbn1+/C1039G mice (n=9). Arrows denote root dimension. Bar= 0.75 mm (B.) Echocardiographic quantification of dimensions at the aortic valve (AoV), aortic root (AoR), sinotubular junction (STJ), and ascending aorta (AscAo) in wild type, Tgfb2+/− and Fbn1+/C1039G mice at 8 months of age. (†p<0.005, †† p<0.001). There was no significant difference in aortic dimension between Tgfb2+/− and Fbn1+/C1039G mice at this age. (C.) Western blot analysis of murine ascending aortas demonstrating increased phosphorylation of Smad2, Smad3, and ERK proteins in 8 month old Tgfb2+/− and Fbn1+/C1039G mice. Graphs representing phosphoprotein western blot quantification standardized to GAPDH expression, Error bars equal 2 SEM, (*p<0.05, **p<0.01, ††p<0.001).