Table I.

Effects of intranasally administered BRD on NNK-induced lung tumors in A/J mice

Group	Treatment	No. of mice	Body weight (g)	Lung tumors
				Incidence	Multiplicity	Reduction in multiplicity (%)a	P*
1	NNK	20	22.2±1.4	100	16.3±2.9
2	NNK + BRD	19	21.7±1.8	100	4.6±2.2	72	P < 0.05
3	Vehicle control	10	21.5±1.2	30	0.3±0.1

All mice, with the exception of mice in group 3, received NNK (intraperitoneally, at a dose of 50mg/kg, twice a week, for a total of two doses) in 0.1ml physiological saline solution. Beginning 1 week after the last dose of NNK, mice in group 2 received BRD intranasally at a dose of 2mg per mouse (0.6mg pure DIM per mouse), twice a week, until termination of the study at week 27 (for a period of 24 weeks). Upon termination of the study, tumors on the surface of the lung were counted and tumor multiplicities were determined.

^*Compared to group 1.

^aCompared with group 1.