Table 1.
—General Characteristics of Children With OSA With and Without Endothelial Dysfunction and of Healthy Control Subjects
| Characteristics | OSAn (n = 25) | OSAab (n = 11) | Control Subjects (n = 35) |
| Age, y | 7.3 ± 2.2 | 7.5 ± 2.5 | 7.4 ± 1.8 |
| Male sex, % | 60 | 64 | 71 |
| White ethnicity, % | 47.1 | 47.0 | 67.9 |
| BMI z score | 1.34 ± 0.31 | 1.47 ± 0.36 | 1.22 ± 0.26 |
| Systolic BP, mm Hg | 109.2 ± 8.2 | 108.8 ± 10.7 | 103.4 ± 7.6 |
| Diastolic BP, mm Hg | 64.7 ± 8.1 | 65.2 ± 7.5 | 60.9 ± 6.2a |
| AHI, events/ h | 17.8 ± 7.1 | 20.2 ± 8.8 | 0.6 ± 0.3a |
| SaO2 nadir, % | 77.5 ± 11.7 | 76.1 ± 8.9 | 91.6 ± 3.7a |
| Total cholesterol, mg/dL | 174.9 ± 36.1 | 178.3 ± 37.8 | 159.4 ± 19.3a |
| HDL cholesterol, mg/dL | 48.2 ± 13.5 | 47.4 ± 14.9 | 54.0 ± 10.3a |
| LDL cholesterol, mg/dL | 114.1 ± 36.2 | 118.5 ± 22.9 | 93.8 ± 19.1a |
| Triglycerides, mg/dL | 106.2 ± 43.5 | 102.5 ± 45.7 | 82.7 ± 31.3a |
| Peak hyperemic response,b s | 30.1 ± 8.3c | 66.7 ± 8.8 | 27.8 ± 6.1a |
Data are mean ± SD. AHI = apnea-hypopnea index; HDL = high-density lipoprotein; LDL = low-density lipoprotein; OSAab = obstructive sleep apnea with delays in postocclusive hyperemic response; OSAn = obstructive sleep apnea with normal hyperemic response; SaO2 = hemoglobin oxygen saturation.
a
P < .01, control subjects vs OSA.
b
Peak hyperemic response time < 45 s or > 45 s was used to determine whether a subject had normal or abnormal endothelial function.7
c
P < .02, OSAab vs OSAn groups.