Table 2.
Systemic and renal vein (RV) levels (mean ± SD) of PRA, NGAL and cytokines in healthy volunteers, EH and RVH patients
| Healthy volunteers |
EH |
RVH |
||||
|---|---|---|---|---|---|---|
| Systemic | Systemic | RV | Systemic | CLK RV | STK RV | |
| PRA (ng/mL/h) | 0.5 ± 0.5 | 7.9 ± 8.1* | 10.3 ± 10.4 | 13.9 ± 13.7* | 15.3 ± 14.5 | 20.0 ± 16.4† |
| NGAL (ng/mL) | 65.6 ± 24.0 | 84.2 ± 44.4 | 66.4 ± 36.7 | 117.0 ± 53.3*,† | 128.3 ± 45.1*,† | 110.5 ± 50.2*,† |
| IF-γ (pg/mL) | 4.8 ± 2.8 | 6.5 ± 4.1 | 5.7 ± 4.7 | 5.8 ± 2.0 | 6.1 ± 3.5 | 9.7 ± 3.4*,†,#,‡ |
| TNF-α (pg/mL) | 3.6 ± 1.6 | 3.9 ± 1.9 | 4.1 ± 2.0 | 4.7 ± 2.1 | 4.9 ± 1.2 | 6.8 ± 2.3*,†,#,‡ |
| TNFR-1 (pg/mL) | 964.1 ± 272.6 | 1104.5 ± 498.4 | 1016.5 ± 449.2 | 1160.0 ± 387.8 | 1115.0 ± 449.4 | 1457.8 ± 859.8*,† |
| MIP-1δ (pg/mL) | 2146.3 ± 2324.4 | 2619.2 ± 1474.5 | 2343.8 ± 1300.8 | 3573.0 ± 2553.6 | 3520.6 ± 3103.2 | 4235.8 ± 3528.0*,†,‡ |
CLK, contralateral kidney; STK, stenotic kidney; IF, interferon; TNF, tumor necrosis factor-α; TNFR, TNF receptor; MIP, macrophage inflammatory protein.
*P ≤ 0.05 versus normal.
†P ≤ 0.05 versus EH (RV).
#P ≤ 0.05 versus RVH (systemic).
‡P ≤ 0.05 versus RVH (CLK).