Table 4.
Urinary markers at baseline and patient response at 12 and 24 months
| UP at Baseline (g/24 h) | UP at 24 months (g/24 h) | α1M (mg/24h) | α1M/UCr (mg/g) | RBP (μg/24h) | RBP/UCr (μg/g) | MALB (mg/24) | FE Alb. | MALB/UCr (mg/g) | IgG (mg/24h) | FE IgG | IgG/UCr (mg/g) | IgM (mg/24h) | FE IgM | IgM/UCr (mg/g) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10 | 8.59 | 0.20 | 12.7 | 29.7 | 93.1 | 217.1 | 1541.1 | 0.087 | 3594.3 | 63.5 | 0.01467 | 148.0 | 0.152 | 0.00101 | 0.354 |
| 12 | 11.33 | 0.14 | 34.4 | 13.1 | 98.8 | 37.8 | 6118.0 | 0.071 | 2339.2 | 107.2 | 0.01009 | 41.0 | 0.860 | 0.00046 | 0.329 |
| 13 | 19.17 | 0.28 | 187.3 | 94.2 | 31314.4 | 15757.6 | 16578.6 | 0.531 | 8342.4 | 722.6 | 0.13685 | 363.6 | 1.328 | 0.00132 | 0.668 |
| 19 | 8.49 | 0.17 | 43.3 | 42.8 | 4226.2 | 4177.8 | 6457.4 | 0.308 | 6383.3 | 278.8 | 0.10179 | 275.6 | 0.877 | 0.00225 | 0.867 |
| 1 | 14.23 | 2.56 | 179.9 | 112.4 | 35800.1 | 22359.6 | 7744.7 | 0.435 | 4837.1 | 800.6 | 0.31579 | 500.0 | 4.336 | 0.00840 | 2.708 |
| 3 | 13.69 | 1.93 | 93.9 | 83.5 | 9867.7 | 8780.2 | 5119.1 | 0.336 | 4554.9 | 380.4 | 0.21736 | 338.5 | 1.651 | 0.00527 | 1.469 |
| 4 | 15.46 | 1.60 | 135.4 | 65.5 | 15704.0 | 7591.2 | 9905.6 | 0.383 | 4788.3 | 604.0 | 0.13870 | 292.0 | 3.524 | 0.00181 | 1.704 |
| 5 | 11.87 | 3.01 | 121.2 | 56.4 | 18873.2 | 8787.9 | 7866.5 | 0.189 | 3662.9 | 357.9 | 0.09390 | 166.7 | 1.568 | 0.00238 | 0.730 |
| 6 | 5.73 | 2.01 | 32.9 | 19.2 | 3794.7 | 2215.9 | 1383.6 | 0.050 | 808.0 | 62.5 | 0.01485 | 36.5 | 0.200 | 0.00100 | 0.117 |
| 9 | 9.88 | 2.70 | 67.3 | 38.1 | 8482.5 | 4801.5 | 7332.9 | 0.216 | 4150.7 | 311.8 | 0.08858 | 176.5 | 1.974 | 0.00096 | 1.118 |
| 11 | 8.33 | 0.35 | 44.0 | 17.2 | 444.7 | 174.0 | 6960.0 | 0.068 | 2723.0 | 105.1 | 0.01061 | 41.1 | 1.618 | 0.00083 | 0.633 |
| 14 | 7.02 | 0.65 | 52.9 | 41.5 | 6628.6 | 5195.1 | 3034.2 | 0.082 | 2378.0 | 162.1 | 0.03530 | 127.1 | 6.753 | 0.00687 | 5.293 |
| 15 | 12.12 | 3.44 | 143.1 | 73.9 | 17483.8 | 9036.7 | 7463.9 | 0.386 | 3857.8 | 853.8 | 0.14571 | 441.3 | 3.924 | 0.00804 | 2.028 |
| 16 | 7.81 | 1.53 | 44.3 | 20.3 | 96.9 | 44.3 | 6040.6 | 0.101 | 2762.4 | 236.4 | 0.01642 | 108.1 | 2.069 | 0.00226 | 0.946 |
| 17 | 16.27 | 1.74 | 197.9 | 129.5 | 42477.6 | 27789.5 | 8270.3 | 0.479 | 5410.5 | 796.5 | 0.33854 | 521.1 | 7.831 | 0.02507 | 5.123 |
| 18 | 26.46 | 2.98 | 203.2 | 90.9 | 14478.1 | 6475.0 | 13080.6 | 0.325 | 5850.0 | 1196.3 | 0.16411 | 535.0 | 13.176 | 0.00746 | 5.893 |
| 8 | 12.76 | 5.70 | 149.1 | 82.8 | 8732.5 | 4851.9 | 11310.0 | 0.442 | 6284.0 | 506.6 | 0.18765 | 281.5 | 1.604 | 0.00470 | 0.891 |
| 2a | 8.05 | 63.5 | 32.5 | 4930.6 | 2522.7 | 5705.7 | 0.114 | 2919.3 | 382.0 | 0.04190 | 195.5 | 2.456 | 0.00145 | 1.257 | |
| 7a | 9.95 | 136.2 | 122.1 | 26874.2 | 24076.9 | 6056.0 | 0.543 | 5425.6 | 821.4 | 0.34728 | 735.9 | 9.911 | 0.01621 | 8.879 | |
| 20 | 9.88 | 5.63 | 41.8 | 25.9 | 1211.6 | 750.8 | 3868.1 | 0.085 | 2397.1 | 108.6 | 0.01678 | 67.3 | 2.585 | 0.00117 | 1.602 |
| Mean | 11.85 | 2.03 | 99.2 | 59.6 | 12580.7 | 7782.2 | 7091.8 | 0.262 | 4173.4 | 442.9 | 0.12184 | 269.6 | 3.420 | 0.00495 | 2.130 |
| SD | 4.85 | 1.71 | 63.0 | 37.0 | 12751.1 | 8358.6 | 3654.8 | 0.173 | 1792.2 | 328.4 | 0.11188 | 196.5 | 3.449 | 0.00615 | 2.329 |
aPatients 2 and 7 were discontinued from the study at 12 and 6 months respectively. Pt #2 went into PR after treatment with Tacrolimus; Pt #7 went into CR after Corticosteroids
+ Cyclophosphamide therapy.
UP = Urinary Protein; α1M = alpha 1 microglobulin; IgG = Immunoglubilin G; FE =Fractional excretion; RBP = Retinol binding protein; MALB = microalbuminuria; IgM = Immunoglobulin M; UCr= Urinary creatinine.
▭, CR; ▭, PR; ▭, LR; ▭, NR; ▭, REL.