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. 2013 Apr 4;11:92. doi: 10.1186/1741-7015-11-92

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Copyright © 2013 2013 Katzav et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Autoantibody levels in sera of factor V Leiden (FVL) and C57/B6 mice. Antiphospholipid syndrome (APS) was induced in female mice by immunization with β₂-glycoprotein I (β₂-GPI), whereas controls were immunized with adjuvant (complete Freund’s adjuvant, CFA) alone. Anti-cardiolipin β2-GPI-dependent (anti-CL(β₂-GPI)) antibodies were measured in APS (FVL^+/+-APS, n = 10), control FVL^+/+ C57BL/6 background (FVL^+/+-control, n = 11), FVL heterozygous APS (FVL^Q/+-APS, n = 8), FVL homozygous APS (FVL^Q/Q-APS n = 7),and FVL heterozygous control (FVL-control, n = 15) mice. Titers were measured at (A) 1 month post-immunization (1mo PI) and (B) 5 months post-immunization (5mo PI). The levels of antibody represent individual and mean ± SE absorbance values for ELISA. The FVL mice, and especially the FVL^Q/Q-APS group, developed significantly higher levels of anti-CL(β₂-GPI) antibodies at 5mo PI compared with the control background mice, in which the levels of antibodies dropped over time.