Table 3.

Association between pigmentation genetic scores and plasma vitamin D, adjusted for age, centre, season of blood draw and population stratification; stratified by time spent outside in the summer.

vitamin D (ng/ml)	skin color score	tanning score	freckling score
change in plasma 25(OH)D per unit increase in genetic score	−0.06	−0.16	−0.27
95% CI	−0.42, 0.29	−0.37, 0.06	−0.52, -0.01
p-value	0.73	0.15	0.04
N=1396 (699 cases/697 controls)
low sun exposure
change in plasma 25(OH)D per unit increase in genetic score	0.48	0.26	−0.31
95% CI	−0.25, 1.21	−0.19, 0.72	−0.82, 0.19
p-value	0.20	0.26	0.22
N=362 (179 cases/183 controls)
medium sun exposure
change in plasma 25(OH)D per unit increase in genetic score	−0.51	−0.56	−0.20
95% CI	−1.11, 0.09	−0.92, −0.21	−0.65, 0.26
p-value	0.10	0.002	0.40
N=401 (202 cases/199 controls)
high sun exposure
change in plasma 25(OH)D per unit increase in genetic score	−0.17	−0.15	−0.33
95% CI	−0.71, 0.37	−0.47, 0.16	−0.70, 0.05
p-value	0.54	0.34	0.09
N=633 (318 cases/315 controls)
p-value for interaction	0.12	0.02	0.94