Table 4.
Association between genetic scores and prostate cancer status (stratified by time spent outside in the summer), stage and grade, adjusted for age at recruitment and population stratification.
| prostate cancer | skin color score | tanning score | freckling score |
|---|---|---|---|
| status (cases/controls) | |||
| ORa | 1.06 | 1.05 | 1.03 |
| 95% CI | 0.99, 1.12 | 1.02, 1.09 | 0.99, 1.08 |
| p-value | 0.08 | 0.004 | 0.17 |
| N=2927 (1136/1791)b | |||
| low sun exposure | |||
| ORa | 0.97 | 0.98 | 1.01 |
| 95% CI | 0.85, 1.10 | 0.91, 1.06 | 0.93, 1.10 |
| p-value | 0.61 | 0.67 | 0.74 |
| N=790 (276/514) | |||
| medium sun exposure | |||
| ORa | 1.06 | 1.11 | 1.03 |
| 95% CI | 0.94, 1.19 | 1.03, 1.19 | 0.95, 1.13 |
| p-value | 0.37 | 0.004 | 0.47 |
| N=734 (268/466) | |||
| high sun exposure | |||
| ORa | 1.14 | 1.07 | 1.05 |
| 95% CI | 1.03, 1.25 | 1.01, 1.13 | 0.98, 1.12 |
| p-value | 0.01 | 0.02 | 0.15 |
| N=1233 (496/737) | |||
| p-value for interaction | 0.11 | 0.05 | 0.74 |
|
stage (0=localised/1=locally advanced) |
|||
| ORa | 0.99 | 0.99 | 1.02 |
| 95% CI | 0.85, 1.15 | 0.90, 1.08 | 0.92, 1.13 |
| p-value | 0.91 | 0.77 | 0.77 |
| N=1136 (1004/132) | |||
| Gleason grade (0:<7/1:≥7) | |||
| ORa | 0.98 | 0.95 | 0.99 |
| 95% CI | 0.88, 1.08 | 0.89, 1.01 | 0.92, 1.06 |
| p-value | 0.65 | 0.09 | 0.71 |
| N=1135 (794/341) |
a
Odds ratio = change in odds per unit increase in genetic score.
b
The difference in sample size with the full dataset (N = 3123) is due to the exclusion of 196 participants who lacked information on disease status.