Table 5.
Candidate regulators in the telomere group of eQTL hotspots
| eQTL Hotspot | Candidate | Differentially Expressed? | Mutations | Function |
|---|---|---|---|---|
|
IV:1500 kb |
YRF1-1 |
6.4e-6 |
5 base insertion 186 nt upstream |
YRF1 gene |
|
X:20 kb |
YJL225C |
1.1e-4 |
10 base insertion 237nt upstream |
YRF1-like gene |
|
XII:780 kb |
EST2 |
No |
5 missense |
Telomerase component, reverse transcriptase |
|
NUP2 |
No |
7 missense |
Nuclear pore protein involved in telomere silencing |
|
|
XII:1070 kb |
SIR3 |
5.3e-3 |
12 missense |
Involved in telomere silencing |
| RIF2 | No | 6 missense | Involved in telomere silencing |