. 2013 Mar 27;12:115. doi: 10.1186/1475-2875-12-115

Table 2.

Mixed effects modelling of the time course of the parasite count in severe P. falciparum malaria

Parameter	Estimate	SE	P-value
Y-axis intercept	5.224	0.102	<0.001
(log initial parasitaemia (LogP₀) /μl)	5.224	0.102	<0.001
Adjunct treatment	−0.466	0.124	<0.001^§
(no exchange transfusion)	−0.466	0.124	<0.001^§
Treatment mode	−0.146	0.137	0.289
(artesunate)	−0.146	0.137	0.289
Parasite elimination rate constant (/h)	−0.041	0.002	<0.001
(parasite clearance time)^@	−0.041	0.002	<0.001
Adjunct treatment	0.004	0.003	0.242^#
(no exchange transfusion)	0.004	0.003	0.242^#
Treatment mode (artesunate)	−0.023	0.004	<0.001*

There was no difference in initial parasitaemia between artesunate and quinine patients, but ^§patients receiving exchange transfusion had higher initial parasitaemia than patients not receiving exchange transfusion. *artesunate had a significant effect on parasite clearance compared to quinine, ^#while institution of exchange transfusion had no significant effect on parasite clearance. ^@fixed effect: LogP ~ t , which reads as LogP(t) = Intercept + k.LogP₀.