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. Author manuscript; available in PMC: 2013 Apr 4.
Published in final edited form as: J Alzheimers Dis. 2013 Jan 1;34(3):691–700. doi: 10.3233/JAD-122143

Fig. 4.

Fig. 4

Cholinergic neuron degeneration in the MSN of APP23 and APPLd2 mice. A) ChAT-immuno-positive neurons in the MSN of APP23 (middle panel, n = 7) and APPLd2 (right panel, n = 8) show fiber deafferentation and retracted neurites compared to age-matched wt controls (left panel, n = 6). Unbiased stereological quantitation of ChAT-immuno-positive cell number (B) and cell-soma volume (C) are depicted (cell number ± SEM; mean volume ± SEM) (wt, n = 6; APP23, n = 7; APPLd2, n = 8). Scale bar, 50 μm. Differences from wt were significant at *p < 0.05; **p < 0.01.