Table 2.
Pathways enriched with driver genes that are associated to over- and under-expressed pathways in GBMs
|
Over-expressed pathways | ||
|---|---|---|
| Enriched pathways | P | Driver genes |
| ERBB1_RECEPTOR_PROXIMAL_PATHWAY |
0.001 |
PIK3CA KRAS EGFR GAB1 |
| VEGFR1_PATHWAY |
0.002 |
PGF PIK3CA NOS3 GAB1 |
| PDGFRBPATHWAY |
0.003 |
PTEN SHB GAB1 PTPRJ PIK3CA |
| TCPTP_PATHWAY |
0.004 |
HGF PIK3CA EGFR GAB1 |
| ERBB1_DOWNSTREAM_PATHWAY |
0.005 |
PIK3CA EGFR GAB1 BRAF KSR1 KRAS |
| IL2_STAT5PATHWAY |
0.019 |
IL2RA CDK6 PIK3CA |
| PI3KPLCTRKPATHWAY |
0.020 |
PIK3CA GAB1 KRAS |
| ERBB1_INTERNALIZATION_PATHWAY |
0.022 |
PIK3CA EGFR KRAS |
| TRKRPATHWAY |
0.023 |
PIK3CA GAB1 NTRK2 KRAS |
| RET_PATHWAY |
0.038 |
PIK3CA RET GAB1 |
| FASPATHWAY |
0.038 |
PIK3CA CASP3 FAS |
| VEGFR1_2_PATHWAY |
0.039 |
PIK3CA SHB NOS3 GAB1 |
| ER_NONGENOMIC_PATHWAY |
0.042 |
PIK3CA NOS3 KRAS |
| TCRRASPATHWAY |
0.045 |
BRAF KRAS |
|
Under-expressed pathways | ||
|
Enriched pathways |
P |
Driver genes |
| ERBB2ERBB3PATHWAY |
0.005 |
PIK3R3 MAPK10 FRAP1 KRAS |
| TCPTP_PATHWAY |
0.006 |
HGF PIK3R3 EGF KDR |
| ET_EGFRPATHWAY |
0.008 |
FRAP1 EGF |
| ERBB1_DOWNSTREAM_PATHWAY |
0.009 |
FRAP1 PIK3R3 EPS8 KSR1 EGF KRAS |
| IL2_1PATHWAY |
0.017 |
IL2RA IL2 PRKCB1 KRAS |
| ERBB1_RECEPTOR_PROXIMAL_PATHWAY |
0.019 |
PIK3R3 EGF KRAS |
| ERBB1_INTERNALIZATION_PATHWAY |
0.027 |
PIK3R3 EGF KRAS |
| TCRRASPATHWAY |
0.027 |
PRKCB1 KRAS |
| CD8TCRDOWNSTREAMPATHWAY |
0.033 |
IL2RA IL2 PRKCB1 KRAS |
| CXCR3PATHWAY |
0.038 |
PIK3R3 FRAP1 KRAS |
| IL2_PI3KPATHWAY |
0.041 |
IL2RA IL2 FRAP1 |
| TELOMERASEPATHWAY | 0.043 | IL2 EGF FRAP1 NBN |
Significantly pooling driver genes that were associated to over-expressed pathways, we found 14 pathways applying Fisher’s exact test (P < 0.05). Analogously, we observed 12 pathways enriched with driver genes that were associated to under-expressed pathways. We annotated all pathways with their corresponding driver genes.