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. 2013 Apr 4;9(4):e1002996. doi: 10.1371/journal.pcbi.1002996

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) 5HPP-33 results exhibiting binding of the ER in human (NR_hER), mouse (NR_mERa) and bovine (NR_bER) in NovaScreen system. Blue diamonds represent half-maximal activity concentrations (AC50). (B) 5HPP-33 targeted estrogen receptor alpha transcription factor activity (ERa_TRANS) and the cis-regulatory estrogen response element (ERE_CIS) construct in the Attagene system. Blue diamonds represent half-maximal activity concentrations (AC₅₀). Overt cytotoxicity is seen at higher test concentrations; these points are flagged as outliers so that they do not contribute to the reported AC₅₀ estimate.