. 2013 Apr 4;9(4):e1002996. doi: 10.1371/journal.pcbi.1002996

Table 4. Dynamic simulation parameters affecting concentration fields and chemotactic responses.

Molecule	Parameter	Cell/Field Type	Symbol	Parameter Value	Equivalent Value	Ref
VEGF165	Diffusion	ECM	D_V	4.0×10⁻²	0.36	[15], [25], [41], [84]
	Decay	ECM	k_V	1.0×10⁻³	1.0×10⁻³
	Secretion	IC	S_V:IC	6.0×10⁻³	6.67×10⁻⁴	[85]
		MC	S_V:MC	5.0×10⁻³	5.55×10⁻⁴	[32]
	Uptake	EC_t	S_V:Ect	−2.0×10⁻³	−2.22×10⁻⁴
		EC_s	S_V:Ecs	−2.0×10⁻³	−2.22×10⁻⁴
	Field coupling	sVEGFR1	n_r	−0.02		[34]
		Proteases	n_p	0.02		[86]
	Chemotactic strength	EC_t	λ_c:V:ECt	600		[43]
		EC_s	λ_c:V:Ecs	300		[43]
VEGF121	Diffusion	ECM	D_Vf	0.18	1.62	[15], [25], [41], [84]
	Decay	ECM	k_Vf	1.0×10⁻³	1.0×10⁻³
	Secretion	EC_s	S_Vf:Ecs	2.0×10⁻³	2.22×10⁻⁴
		IC	S_Vf:IC	5.0×10⁻³	5.55×10⁻⁴	[85]
		MC	S_Vf:MC	5.0×10⁻³	5.55×10⁻⁴	[32]
	(on contact)	EC_s:MC	S_Vf:Ecs:MC	4.0×10⁻³	4.44×10⁻⁴	[32]
	Uptake	EC_t	S_Vf:Ect	−2.0×10⁻³	−2.22×10⁻⁴
		EC_s	S_Vf:Ecs	−2.0×10⁻³	−2.22×10⁻⁴
	Chemotactic strength	EC_t	λ_c:Vf:ECt	400		[43]
		EC_s	λ_c:Vf:Ecs	200		[43]
CCL2	Diffusion	ECM	D_C	8.0×10⁻²	0.72
	Decay	ECM	k_C	2×10⁻³	2×10⁻³
	Secretion	EC_t	S_C:Ect	4.0×10⁻³	4.44×10⁻⁴	[87], [88]
		EC_s	S_C:Ecs	2.0×10⁻³	2.22×10⁻⁴	[87], [88]
		IC	S_C:IC	6.0×10⁻³	6.67×10⁻⁴	[87]
	(on contact)	MC:IC	S_C:MC:IC	1.0×10⁻³	1.11×10⁻⁴	[46]
	(on contact)	IC:MC	S_C:IC:MC	1.0×10⁻³	1.11×10⁻⁴	[46]
	Chemotactic strength	EC_t	λ_c:C:ECt	400		[39], [45]
		EC_s	λ_c:C:Ecs	200		[39], [45]
		IC	λ_c:C:IC	400		[39], [45]
CXCL10	Diffusion	ECM	D_Cx	8.0×10⁻²	0.72
	Decay	ECM	k_Cx	2×10⁻³	2×10⁻³
	Secretion	IC	S_Cx:IC	5.0×10⁻³	5.55×10⁻⁴	[87]
		MC	S_Cx:MC	3.0×10⁻³	3.33×10⁻⁴	[87]
sVEGFR1	Diffusion	ECM	D_r	0.14	1.26
	Decay	ECM	k_r	4×10⁻³	4×10⁻³
	Secretion	EC_s	S_r:Ecs	2.0×10⁻³	2.22×10⁻⁴	[38]
	Chemotactic strength	EC_t	λ_c:r:ECt	−200		[34]
Proteases	Diffusion	ECM	D_p	0.2	1.8
	Decay	ECM	k_p	5×10⁻³	5×10⁻³
	Secretion	EC_t	S_p:Ect	1.0×10⁻²	1.11×10⁻³	[89]
		EC_s	S_p:Ecs	1.0×10⁻³	1.11×10⁻⁴	[89]
	(on contact)	EC_t:IC	S_p:Ect:IC	1.0×10⁻²	1.11×10⁻³	[31], [38]
	Chemotactic strength	IC	λ_c:r:IC	−200
TIE2	Diffusion	ECM	D_T	0.1	0.9
	Decay	ECM	k_T	5×10⁻³	5×10⁻³
	Secretion	EC_t	S_T:Ect	5.0×10⁻³	5.55×10⁻⁴	[90]
		EC_s	S_T:Ecs	1.0×10⁻³	1.11×10⁻⁴	[90]
	Chemotactic strength	MC	λ_c:T:MC	100		[35]

Diffusion units are pix²/s and µm²/s, decay units are MCS⁻¹ and s⁻¹, and secretion and uptake units are c.u./pix²/s and c.u./µm²/s, for parameter and equivalent values, respectively (c.u. is arbitrary concentration units). Parameter values were informed by experimental observations and in most cases estimated to achieve relative steady state concentrations that approximated measured serum levels. References correspond to measured values (diffusion, secretion) or observed behaviors (field coupling, chemotactic strength). EC_t: endothelial tip cells, EC_s: endothelial stalk cells, IC: inflammatory cells, MC: mural cells, ECM: extracellular matrix.