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. 2013 Apr 4;9(4):e1003001. doi: 10.1371/journal.pcbi.1003001

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© 2013 Inoue and Kaneko

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(upper) An example of cooperative adaptive networks with which does not include the minimal adaptive motifs of 3 genes at any part of the gene regulatory network, but shows adaptive behaviors for all genes (except the input gene). The input () acts on the input gene () and the target gene is . Interactions between genes are shown by arrows; arrows with solid red lines show activation, whereas arrows with broken blue lines show suppression. (lower left panel) An example of a substructure showing a similar role with the minimal adaptive motifs extracted from the upper network. For reference, a related adaptive motif with 3 genes ( in Figure 6) was redrawn (lower right panel).

Inline graphic — (upper) An example of cooperative adaptive networks with which does not include the minimal adaptive motifs of 3 genes at any part of the gene regulatory network, but shows adaptive behaviors for all genes (except the input gene). The input () acts on the input gene () and the target gene is . Interactions between genes are shown by arrows; arrows with solid red lines show activation, whereas arrows with broken blue lines show suppression. (lower left panel) An example of a substructure showing a similar role with the minimal adaptive motifs extracted from the upper network. For reference, a related adaptive motif with 3 genes ( in Figure 6) was redrawn (lower right panel).