Table 1.

Inclusion and exclusion criteria of the BEST study

Inclusion criteria	Exclusion criteria
• Female patients with histologically confirmed primary breast cancer, stage I-III after lumpectomy or mastectomy scheduled for adjuvant radiotherapy at the University of Heidelberg Medical Center	• Acute infectious disease
	• Inability to walk or stand
	• Severe neurological deficiencies
• Age ≥18 years of age	• Severe cardiac or cardiovascular disease
• BMI ≥18 kg/m2	• Severe respiratory insufficiency
• Ability to understand and follow the study protocol	• Severe renal failure
• Willingness to come to the Heidelberg exercise facilities and adhere to study protocol	• Other concurrent malignant disease (except carcinoma in situ of skin or cervix)
• Written informed consent	• Substance abuse (potentially leading to non-compliance)
	• Participation in systematic intense resistance or aerobic training (at least 1 h twice per week)
	• Previous participation in another exercise intervention trial