Table 3.
Safety of triptolide treatment
| Con | TP | DM | DM + TP,L | DM + TP,M | DM + TP,H | |
|---|---|---|---|---|---|---|
| ALT, U/l |
44.7 ± 13.3 |
42.2 ± 12.1 |
72.4 ± 13.5* |
76.5 ± 20.1* |
84.5 ± 13.6* |
89.6 ± 11.5* |
| AST, U/l |
110.0 ± 41.0 |
114.0 ± 46.1 |
144.0 ± 59.0 |
141.2 ± 43.6 |
167.7 ± 57.3 |
167.4 ± 60.2 |
| Cr, μmol/l |
53.3 ± 13.8 |
51.5 ± 11.7 |
56.4 ± 15.4 |
41.8 ± 13.1 |
42.6 ± 8.2 |
40.2 ± 7.4 |
| CK-MB, U/l | 593.2 ± 158.1 | 538.2 ± 234.7 | 714.7 ± 132.3 | 322.0 ± 53.3*# | 450.2 ± 90.8# | 517.4 ± 79.7 |
TP, L low-dose triptolide (100 μg/kg/day), TP, M medium-dose triptolide (200 μg/kg/day), TP, H high-dose triptolide (400 μg/kg/day). *P < 0.05 versus Con; #P < 0.05 versus DM.