Table 3.
Mortality in FEAST A presented in each IDMC report
| |
Comparisons between arms for mortality at 48 hours |
||||||
|---|---|---|---|---|---|---|---|
| |
Mortality in each arm |
|
Primary endpoint |
Secondary endpoint |
|||
| Meeting | Albumin | Saline | Control | Total | Risk ratio for saline bolus versus no bolus | Risk ratio for albumin bolus versus saline bolus | Risk ratio bolus versus no bolus |
| 18 June 2009 (data to 13 May 2009); N = 406 |
12/137 (8.8%) |
14/136 (10.3%) |
18/133 (13.5%) |
44/406 (10.8%) |
0.76 (0.39 to 1.47);P = 0.41 |
0.87 (0.42 to1.81); P = 0.71 |
0.70 (0.40 to 1.24); P = 0.22 |
| 12 October 2009 (data to 31 August 2009); N = 844 |
30/283 (10.6%) |
28/282 (9.9%) |
31/279 (11.1%) |
89/844 (10.5%) |
0.89 (0.06 to 1.45); P = 0.65 |
1.07 (0.66 to 1.74); P = 0.79 |
0.92 (0.61 to 1.39); P = 0.71 |
| 26 January 2010 (data to 31 December 2009); N = 1,337 |
50/444 (11.3%) |
46/445 (10.3%) |
43/448 (9.6%) |
139/1337 (10.4%) |
1.07 (0.73 to 1.60); P = 0.71 |
1.09 (0.75 to 1.59); P = 0.66 |
1.13 (0.78 to 1.58); P = 0.50 |
| 26 July 2010 (data to 15 June 2010); N = 2,196 |
74/732 (10.1%) |
74/733 (10.1%) |
56/731 (7.7%) |
204/2196 (9.3%) |
1.32 (0.95 to 1.84); P = 0.10 |
1.001 (0.74 to 1.36); P = 0.99 |
1.32 (0.98 to 1.77); P = 0.06 |
| 12 January 2011 (data to 15 November 2010); N = 2,987 | 101/989 (10.2%) | 101/989 (10.2%) | 69/989 (7.0%) | 271/2987 (9.1%) | 1.46 (1.09 to 1.96);P = 0.01 | 1.00 (0.77 to 1.30); P = 1.0 | 1.46 (1.13 to 1.90);P = 0.004 |