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JS-K inhibits proliferation in U87 cells in vivo. a) The number of Ki-67-positive, proliferation active cells is shown for untreated control rats (Ctr, black, n=4) and JS-K treated rats (grey, n=4, *** p 0.001). b) Immunohistochemistry for Ki-67 illustrating the JS-K-dependent reduction of proliferating cells (green) within the tumor in a JS-K treated rat (right) compared to a control animal (left). Cell nuclei were counterstained with DAPI (magnification 20, scale bar = 50 m).
