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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2013 Jan 31;22(4):708–718. doi: 10.1158/1055-9965.EPI-12-1234-T

Figure 6.

Figure 6

Males (n=54), who have reduced CYP2A6 activity compared to females (n=127), had a greater ratio of cotinine formation over cotinine removal, which would result in the accumulation of cotinine and higher cotinine levels at a given tobacco exposure in male smokers (Study 1). A. The fNIC→COT did not differ between the sexes. B. Males had significantly lower ClCOT compared to the females. C. Males had a higher fNIC→COT/CLCOT compared to females indicating an over-estimation of nicotine dose for their cotinine levels (see Fig 1D). Data presented as mean ± 95% confidence interval.