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Schematic cartoon of the NMDA GluN2B subunit. The extracellular N-terminus, four transmembrane domains denoted by the four blue boxes, and the intracellular C-terminus are depicted in the diagram. Red circles on the intracellular C-terminus indicate the approximate location of tyrosine residues 1252, 1336, and 1472. Also depicted are comparisons of wild-type (top) and mutant (bottom) amino acid sequences for each mutation studied.
