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Current-voltage relationship of wild-type and phospho-mutant NMDARs. (A) Cells were voltage clamped at 0 mV and then stepped to −80 mV for 200 ms followed by a 1.3s ramp to +80 mV for another 200 ms before returning to 0 mV. All recordings were performed in the presence of 2 mM Mg++. (N = 7 – 9 cells) (B) Current-voltage relationship of wild-type and mutant receptors after normalizing current to that obtained at +80 mV.
