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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Alcohol. 2013 Jan 26;47(3):181–186. doi: 10.1016/j.alcohol.2012.12.015

Table 1.

Functional characteristics of mutant and wild-type receptors. Values for peak current, steady-state current, and steady-state to peak ratio are presented as mean ± SEM (N). While no significant effect in peak current amplitude was observed, one-way ANOVA did reveal a significant overall effect in steady-state current amplitude and steady-state to peak ratio (p = 0.032, p = 0.034 respectively). Dunnett’s post-hoc testing, however, demonstrated no significant effect between pair-wise comparisons of wild-type and mutant receptors.

NR1-1a
Mutant Expressed Peak Current, PA Steady-state Current, pA SS: Peak Ratio
NR2B-WT −261.6 ± 19.6 (41) −182.4 ± 14.0 (41) 0.70 ± 0.02 (41)
Y1472F −226.1 ± 26.3 (22) −152.4 ± 18.9 (22) 0.67 ± 0.02 (22)
Y1336F −205.6 ± 23.6 (25) −134.7 ± 15.8 (25) 0.65 ± 0.02 (25)
Y1252F −280.6 ± 17.6 (17) −215.1 ± 14.2 (17) 0.78 ± 0.04 (17)
Triple Mutant −305.8 ± 59.4 (20) −190.4 ± 27.9 (20) 0.68 ± 0.04 (20)