Table 2.

miRNAs and factors that affect radiosensitivity

miRNAs	more sensitive to IR	less sensitive to IR	change in expression
AGO2	knockdown of AGO2 [44]		n/a
DICER	knockdown of DICER [44]		n/a
let-7a	pre-let-7a [37]		varied (increase [22], decrease [18,21,26])
let-7g	pre-let-7g [16,25,38]	anti-let-7g [25]	varied (increase [20–25], decrease [15,18])
miR-7	pre-miR-7 [68]	anti-miR-7 [68]	n/a
miR-9	miR-9 overexpression [16]		*decrease [16]
miR-17-92		miR-17-92 cluster overexpression [69]	*increase [15,17,22,23,25,26,34]
miR-18a	miR-18a overexpression [52]	miR-18a inhibitor [52]	varied [17]
miR-21	miR-21 inhibitor [40]		*increase [17,21–23,25,34]
miR-34b	miR-34b overexpression [39]		n/a
miR-100	miR-100 overexpression [51]		*decrease [19,21,31]
miR-101	miR-101 overexpression [50]	miR-101/-101* inhibitors [50]	increase [23]
miR-125a	anti-miR-125a [25]	pre-miR-125a [25]	decrease [25,26]
miR-127	pre-miR-127 [25]	anti-miR-127 [25]	*decrease [25]
miR-138	miR-138 mimic [55]		n/a
miR-155	anti-miR-155 [64]	pre-miR-155 [64]	varied (increase [17,22,64], decrease [17,26])
miR-181a	miR-181a overexpression [24]		*decrease [19,24]
miR-189	anti-miR-189 [25]	pre-miR-189 [25]	decrease [25]
miR-216a	miR-216a inhibitor [44]		*increase [44]
miR-221/222	anti-miR-221/222 [70]	pre-miR-221/222 [70]	*miR-221 increase [19,23,26,34] *miR-222 increase [23,34]
miR-421	miR-421 overexpression [49]		increase [19]
miR-518-5p	miR-518-5p inhibitor [44]		*increase [44]
miR-521	miR-521 mimic [31]	miR-521 inhibitor [31]	*decrease [24,31]
miR-525-3p	miR-525-3p inhibitor [44]		*increase [44]
miR-628-5p	miR-628-5p inhibitor [44]		*increase [44]