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. 2013 Apr 4;9(4):e1003444. doi: 10.1371/journal.pgen.1003444

Figure 2. rs2228145 regulates the expression of the ds-IL6R but not the fl-IL6R isoform.

Figure 2

(A) Expression of fl-IL6R and (B) ds-IL6R relative to the housekeeping gene B2M was measured by quantitative real-time PCR of RNA purified from PBMCs of 88 healthy volunteers from the Cambridge BioResource. Individual expression levels and their mean (±SEM) are plotted according to rs2228145 genotype. Differences in the mean expression levels relative to the common homozygotes group (Asp/Asp) are indicated above the black horizontal lines. P-values represent test for an association of rs2228145 with the expression levels of fl-IL6R or ds-IL6R, using an additive allelic effects model. AU, arbitrary units.