Figure 5. Network reconstruction for STAT1 signaling in scleroderma.

TLR signaling is activated by STAT1, which in turn activates IFN signaling, resulting in increased STAT1 activity. Predicted drug targets (within the top 100) for scleroderma are highlighted with colored stars, where the numbers correspond to the rank in the drug target predictions. Cyan stars represent known drug targets for scleroderma. Purple stars correspond to drug targets that have been associated with other diseases and can be readily repositioned to the treatment of scleroderma, while yellow stars indicate unexploited drug targets that can be used for the development of novel treatment strategies. Red thermometers show significantly up-regulated genes in scleroderma, blue thermometers show down-regulated genes. Green arrows correspond to activation edges, red arrows represent inhibition edges.