Table 2. Top drug target predictions for the 30 diseases.
| Disease Name | Top Drug Target Prediction | AUC | Baseline AUC |
| Hyperplastic polyposis syndrome | SP1 | 93.19 | 69.83 |
| Periodontitis | Atp6v1c2 | 90.98 | 54.27 |
| Scleroderma | STAT1 | 90.39 | 55.48 |
| Idiopathic pulmonary fibrosis | PTPR-beta | 88.26 | 53.34 |
| Thyroid carcinoma | c-Myc | 85.67 | 54.03 |
| AIDS | LSm complex | 84.94 | 53.29 |
| Ischemic cardiomyopathy | eIF1AY | 84.92 | 58.14 |
| Ovarian cancer | Intelectin-1 | 83.83 | 57.33 |
| Sickle-cell disease | Dynactin complex | 82.07 | 64.72 |
| Acute myeloid leukemia | SP1 | 81.95 | 51.62 |
| Melanoma | c-Myc | 81.63 | 51.75 |
| Sjogren's syndrome | P53 | 81.44 | 57.71 |
| Colorectal cancer | c-Myc | 81.13 | 51.08 |
| Hepatocellular carcinoma | P53 | 80.19 | 51.88 |
| Psoriasis | 5T4 | 79.25 | 50.94 |
| Melanoma with metastasis | c-Myc | 78.79 | 52.55 |
| Septic shock | c-Jun | 78.68 | 52.32 |
| HIV | STAT1 | 77.64 | 51.33 |
| Obesity | SP1 | 76.65 | 51.48 |
| Malaria | c-Myc | 75.79 | 51.33 |
| Systemic lupus erythematosus | STAT1 | 75.28 | 53.03 |
| Parkinson's disease | Olfactory receptor | 75.16 | 51.35 |
| Sarcoidosis | c-Myc | 74.06 | 56.15 |
| Diabetes type 1 | EGR2 (Krox20) | 72.89 | 52.58 |
| Hepatitis C | c-Myc | 72.15 | 51.46 |
| Ulcerative colitis | c-Jun | 71.74 | 52.14 |
| Multiple sclerosis | P53 | 71.51 | 50.94 |
| Crohns disease | VPS52 | 68.44 | 52.19 |
| Liver cirrhosis | STAT1 | 67.47 | 54.85 |
| Ischemic stroke | CLEC2D | 63.27 | 51.18 |
For each disease, the name of the predicted drug target obtained from MetaBase and the AUC performance together with the respective baseline AUC performance (based on permutation testing) is shown.